AOD-9604
In stock5 mg · Lyophilized powder
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Modified fragment of human growth hormone (176–191).
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For laboratory research use only by qualified researchers. Not for human or veterinary use. Not a drug, dietary supplement, cosmetic or food. Not evaluated by the FDA for any use.
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Quick Summary
Investigational — never approvedAOD-9604 is a synthetic peptide based on the tail end (amino acids 176–191) of human growth hormone. It was developed as a possible obesity drug meant to keep growth hormone's fat-metabolism effects without its effects on growth or blood sugar. Human studies focused on safety, efficacy results are largely unpublished, and it was never approved.
Areas of research
- Obesity and fat metabolism
- Growth hormone structure-function
- Human safety and tolerability
- Anti-doping science
- Amount
- 5 mg
- Form
- Lyophilized powder
- References
- 4 cited
- COA
- Batch report pending
- Free U.S. shipping on orders of $150 or more
- Lyophilized powder in a sealed vial
Research Use Notice. This product is intended for laboratory and research purposes. It is not intended for human consumption or personal medical use. Product information is provided for scientific and educational context only. See our Research Use Policy.
Why Researchers Study It
- Separating growth hormone's fat-metabolism effects from its effects on growth
- Fat breakdown (lipolysis) in obese mouse models
- A possible role for the beta-3 adrenergic receptor, seen in mouse studies
- Human safety and tolerability studies
What It Is
AOD-9604 is a synthetic peptide based on a short section from the tail (C-terminal) end of human growth hormone.
AOD-9604 is a synthetic peptide based on a short section from the tail (C-terminal) end of human growth hormone. It was developed by an Australian company as a possible obesity drug.
The idea was to keep the fat-related effects attributed to that region of growth hormone, without the hormone's effects on growth or blood sugar. It has never been approved as a medicine.
Early work suggested that the tail end of growth hormone carries much of its fat-breakdown (lipolytic) activity. In obese mice, both growth hormone and AOD-9604 reduced body weight and body fat over two weeks.
Later human studies, reported by authors affiliated with the developer, focused on safety. Published efficacy results for weight loss in people are scarce.
How It Works
0 established · 3 proposed or under investigation
Established
No mechanism of action has been firmly established for AOD-9604.
Proposed / under investigation
- Increases fat breakdown and fat oxidation in obese mice
- Chronic effects in mice appeared to depend on the beta-3 adrenergic receptor, since they were absent in mice lacking that receptor
- Reported not to raise IGF-1 or impair glucose handling in human safety studies, unlike full growth hormone
Research Status & Evidence
Investigational — never approved
Mechanism data come mostly from mouse studies. Human trials reported safety and tolerability, not published efficacy results.
Types of evidence
- Not available: Cell & lab studies
- Available: Animal studies
- Not available: Early human studies
- Available: Clinical trials
- Not available: Approved medical use
Mechanistic evidence comes mainly from mouse studies by one Australian research group. Six placebo-controlled human trials were pooled in a safety paper written with the developer; it reported placebo-like tolerability but did not present efficacy data. There is no approved use.
Areas of research
- Obesity and fat metabolismrodent models of lipolysis
- Growth hormone structure-functionseparating fat effects from growth effects
- Human safety and tolerabilitysix placebo-controlled trials
- Anti-doping sciencelisted by WADA as a growth hormone fragment
Limitations
- Not approved by the FDA or any other regulator as a drug
- Peer-reviewed human efficacy data for weight loss are largely unpublished; the main human paper covers safety only and has developer-affiliated authors
- Mechanism is based mostly on rodent studies and has limited independent replication
- Prohibited at all times in sport under the WADA Prohibited List
Specifications
5 mg · Lyophilized powder · CAS 221231-10-3
- Product
- AOD-9604
- Category
- Peptides
- Size
- 5 mg
- Form
- Lyophilized powder
- Synonyms
- AOD9604; hGH fragment 176–191 (modified); AOD 9604
- CAS number
- 221231-10-3
- Molecular formula
- C78H123N23O23S2
- Molecular weight
- 1815.1 g/mol
- PubChem CID
- 71300630
- SKU
- REN-AOD-5
Molecular data: Free peptide, not the acetate salt (PubChem).
Testing & COA Batch report pending
Research References (4)
Linked sources · last reviewed September 2026
- Heffernan M et al. Effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism in obese mice and beta3-AR knock-out mice. Endocrinology 2001 · academic.oup.com
- Stier H, Vos E, Kenley D. Safety and tolerability of the hexadecapeptide AOD9604 in humans. J Endocrinol Metab 2013 · jofem.org
- FDA. Certain bulk drug substances for use in compounding that may present significant safety risks (updated April 2026) · fda.gov
- WADA. The 2026 Prohibited List, section S2.2.3 (copy published by JADCO) · jadco.gov.jm
Summaries are written by Renuvia Labs from the sources above for educational context only. Last reviewed September 28, 2026.
Frequently Asked Questions
What is AOD-9604?
AOD-9604 is a synthetic peptide based on the tail end (amino acids 176–191) of human growth hormone. It was developed as a possible obesity drug meant to keep growth hormone's fat-metabolism effects without its effects on growth or blood sugar. Human studies focused on safety, efficacy results are largely unpublished, and it was never approved.
Is there a AOD-9604 coupon or discount code?
There is no public coupon code. New customers get a first-order discount for joining the Renuvia email list, volume pricing starts at 2 vials of AOD-9604, and U.S. shipping is free over $150. Codes on third-party coupon sites are not valid here.
What are other names for AOD-9604?
AOD-9604 is also referred to as AOD9604, hGH fragment 176–191 (modified), AOD 9604.
What are the CAS number and molecular weight of AOD-9604?
AOD-9604: CAS number 221231-10-3; molecular formula C78H123N23O23S2; molecular weight 1815.1 g/mol; PubChem CID 71300630. (Free peptide, not the acetate salt (PubChem).)
What sizes is Renuvia Labs AOD-9604 available in?
AOD-9604 is listed in 5 mg, supplied as lyophilized powder in a sealed glass vial. It is sold for laboratory research use only.
Where is the Certificate of Analysis for AOD-9604?
Certificates of Analysis are published per lot in the Renuvia Labs COA library, searchable by product, SKU or lot number. AOD-9604 shows "pending" there until the current lot's report exists; it is then linked on this page too.
Is this in stock?
Yes, unless the page says sold out. You reserve it with no payment today, and we email payment instructions in approximately 1–2 business days. Your order ships once payment arrives.
What form is this product supplied in?
Peptides and research compounds ship as lyophilized (freeze-dried) powder in a sealed glass vial. The fill amount printed on the product page and label is the total content of the vial.
Is this product for human use?
No. All Renuvia Labs products are sold strictly for laboratory research use. They are not for human or animal consumption and are not intended to diagnose, treat, cure or prevent any disease.
Do you offer volume pricing?
Yes. Per-vial pricing drops automatically at 2, 3 and 5 vials of the same product; the current tiers are shown next to the price. For larger quantities, see our wholesale program.
How much is shipping?
Free U.S. shipping on orders of $150 or more; $8.95 flat rate below that.
Do you ship outside the U.S.?
No. Renuvia Labs ships to U.S. addresses only. Research institutions outside the U.S. can enquire through the wholesale program.
