Ipamorelin
In stock10 mg · Lyophilized powder
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Synthetic pentapeptide ghrelin-receptor (GHS-R) agonist.
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For laboratory research use only by qualified researchers. Not for human or veterinary use. Not a drug, dietary supplement, cosmetic or food. Not evaluated by the FDA for any use.
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Quick Summary
Investigational — never approvedIpamorelin is a synthetic five-amino-acid peptide that activates the ghrelin receptor (GHS-R1a), a switch in the pituitary gland that triggers growth hormone release. Researchers were interested because, in animals, it released growth hormone without also raising the stress hormones ACTH and cortisol. It reached phase 2 human trials but was never approved.
Areas of research
- Growth hormone release
- Pituitary hormone signaling
- Postoperative ileus
- Anti-doping science
- Amount
- 10 mg
- Form
- Lyophilized powder
- References
- 4 cited
- COA
- Published
- Free U.S. shipping on orders of $150 or more
- Lyophilized powder in a sealed vial
- Batch COA available
Research Use Notice. This product is intended for laboratory and research purposes. It is not intended for human consumption or personal medical use. Product information is provided for scientific and educational context only. See our Research Use Policy.
Why Researchers Study It
- Selective growth hormone release compared with older growth hormone-releasing peptides
- Ghrelin receptor signaling in the pituitary gland
- Ghrelin-like effects on gut movement after bowel surgery (negative phase 2 trial)
- Anti-doping detection, as a substance on WADA's prohibited list
What It Is
Ipamorelin is a small synthetic peptide made of five amino acids, including several unnatural building blocks.
Ipamorelin is a small synthetic peptide made of five amino acids, including several unnatural building blocks. It was developed at Novo Nordisk in the 1990s under the code NNC 26-0161.
It belongs to a family of compounds called growth hormone secretagogues, which act on the same receptor as the stomach hormone ghrelin. It has never been approved as a medicine in any country.
Ipamorelin drew attention because it was the first compound of its class reported to trigger growth hormone release without also raising the stress hormones ACTH and cortisol. Older related peptides, such as GHRP-6 and GHRP-2, raised those hormones as well.
Because ghrelin also affects gut movement, the compound was later tested in people recovering from bowel surgery. That clinical program did not show a clear benefit over placebo.
How It Works
2 established · 1 proposed or under investigation
Established
- Activates the growth hormone secretagogue (ghrelin) receptor in the pituitary, releasing growth hormone in rat cells, rats and pigs
- In those animal studies, it did not significantly raise ACTH or cortisol, even at exposures far above those needed for growth hormone release
Proposed / under investigation
- Ghrelin-like effects on gut motility, investigated in rodent models and a human postoperative ileus trial that did not meet its main goal
Research Status & Evidence
Investigational — never approved
Selectivity data come from rat and pig studies. A phase 2 trial in bowel-surgery patients found no significant difference from placebo.
Types of evidence
- Available: Cell & lab studies
- Available: Animal studies
- Not available: Early human studies
- Available: Clinical trials
- Not available: Approved medical use
The core selectivity data come from one company's preclinical work in rat pituitary cells, rats and pigs. The main published human efficacy trial, a phase 2 study of 117 bowel-surgery patients funded by Helsinn, found no significant difference from placebo. Long-term human data are lacking.
Areas of research
- Growth hormone releaseselectivity versus older GH-releasing peptides
- Pituitary hormone signalingghrelin receptor pharmacology
- Postoperative ileusgut recovery after bowel surgery (negative trial)
- Anti-doping sciencelisted by WADA as a prohibited GH secretagogue
Limitations
- Not approved by the FDA or any other regulator for any use
- The published phase 2 trial in bowel surgery found no significant difference from placebo on its main or secondary measures
- FDA lists ipamorelin acetate among bulk substances that may present significant safety risks in 503B compounding, citing immunogenicity and a literature report of serious adverse events including death with intravenous use
- Prohibited at all times in sport under the WADA Prohibited List
Specifications
10 mg · Lyophilized powder · CAS 170851-70-4
- Product
- Ipamorelin
- Category
- Peptides
- Size
- 10 mg
- Form
- Lyophilized powder
- Synonyms
- NNC 26-0161
- CAS number
- 170851-70-4
- Molecular formula
- C38H49N9O5
- Molecular weight
- 711.9 g/mol
- Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH2
- PubChem CID
- 9831659
- SKU
- REN-IPA-10
Molecular data: Free peptide, not the acetate salt (PubChem).
Testing & COA Batch report available
- Batch VB-2609-01-FI · HPLC-DAD · Supplier COA (KMD Analytical) · 2026-10-0699.99% purity · Identity: confirmed · 10.74 mg measured (107.4% of label)View COA
Research References (4)
Linked sources · last reviewed September 2026
- Raun K et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol 1998 · PubMed 9849822
- Beck DE et al. Proof-of-concept study of the ghrelin mimetic ipamorelin for postoperative ileus in bowel resection patients. Int J Colorectal Dis 2014 · PubMed 25331030
- FDA. Certain bulk drug substances for use in compounding that may present significant safety risks (updated April 2026) · fda.gov
- WADA. The 2026 Prohibited List, section S2.2.4 (copy published by JADCO) · jadco.gov.jm
Summaries are written by Renuvia Labs from the sources above for educational context only. Last reviewed September 28, 2026.
Frequently Asked Questions
What is Ipamorelin?
Ipamorelin is a synthetic five-amino-acid peptide that activates the ghrelin receptor (GHS-R1a), a switch in the pituitary gland that triggers growth hormone release. Researchers were interested because, in animals, it released growth hormone without also raising the stress hormones ACTH and cortisol. It reached phase 2 human trials but was never approved.
Is there a Ipamorelin coupon or discount code?
There is no public coupon code. New customers get a first-order discount for joining the Renuvia email list, volume pricing starts at 2 vials of Ipamorelin, and U.S. shipping is free over $150. Codes on third-party coupon sites are not valid here.
What are other names for Ipamorelin?
Ipamorelin is also referred to as NNC 26-0161.
What are the CAS number and molecular weight of Ipamorelin?
Ipamorelin: CAS number 170851-70-4; molecular formula C38H49N9O5; molecular weight 711.9 g/mol; PubChem CID 9831659. Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2. (Free peptide, not the acetate salt (PubChem).)
What sizes is Renuvia Labs Ipamorelin available in?
Ipamorelin is listed in 10 mg, supplied as lyophilized powder in a sealed glass vial. It is sold for laboratory research use only.
Where is the Certificate of Analysis for Ipamorelin?
Certificates of Analysis are published per lot in the Renuvia Labs COA library, searchable by product, SKU or lot number. Ipamorelin shows "pending" there until the current lot's report exists; it is then linked on this page too.
Is this in stock?
Yes, unless the page says sold out. You reserve it with no payment today, and we email payment instructions in approximately 1–2 business days. Your order ships once payment arrives.
What form is this product supplied in?
Peptides and research compounds ship as lyophilized (freeze-dried) powder in a sealed glass vial. The fill amount printed on the product page and label is the total content of the vial.
Is this product for human use?
No. All Renuvia Labs products are sold strictly for laboratory research use. They are not for human or animal consumption and are not intended to diagnose, treat, cure or prevent any disease.
Do you offer volume pricing?
Yes. Per-vial pricing drops automatically at 2, 3 and 5 vials of the same product; the current tiers are shown next to the price. For larger quantities, see our wholesale program.
How much is shipping?
Free U.S. shipping on orders of $150 or more; $8.95 flat rate below that.
Do you ship outside the U.S.?
No. Renuvia Labs ships to U.S. addresses only. Research institutions outside the U.S. can enquire through the wholesale program.
