KPV
In stock10 mg · Lyophilized powder
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C-terminal tripeptide (Lys-Pro-Val) of α-MSH.
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For laboratory research use only by qualified researchers. Not for human or veterinary use. Not a drug, dietary supplement, cosmetic or food. Not evaluated by the FDA for any use.
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Quick Summary
Preclinical — no human dataKPV is a three-amino-acid peptide (lysine-proline-valine) taken from the end of α-MSH, a hormone with anti-inflammatory activity. It has been studied in intestinal cells and mouse models of colitis for its effects on inflammatory signaling. There are no human studies, and it is not approved.
Areas of research
- Intestinal inflammation
- Peptide transport
- Inflammatory signaling
- Amount
- 10 mg
- Form
- Lyophilized powder
- References
- 3 cited
- COA
- Published
- Free U.S. shipping on orders of $150 or more
- Lyophilized powder in a sealed vial
- Batch COA available
Research Use Notice. This product is intended for laboratory and research purposes. It is not intended for human consumption or personal medical use. Product information is provided for scientific and educational context only. See our Research Use Policy.
Why Researchers Study It
- Keeping part of α-MSH's anti-inflammatory activity in a much smaller molecule
- Uptake into gut-lining cells through the peptide transporter PepT1
- NF-κB inflammatory signaling in intestinal cells
- Mouse models of colitis
What It Is
KPV is a tripeptide made of lysine, proline and valine.
KPV is a tripeptide made of lysine, proline and valine. It is the last three amino acids (positions 11 to 13) of alpha-melanocyte-stimulating hormone (α-MSH).
It has no approved medical use and has been studied almost entirely in cells and animals.
α-MSH has anti-inflammatory activity, and researchers found that this small C-terminal piece keeps some of that activity. KPV is of interest because it is small enough to be carried into gut-lining cells by a peptide transporter.
Most work has examined inflammation in intestinal cells and mouse models of colitis.
How It Works
1 established · 2 proposed or under investigation
Established
- Taken up into intestinal epithelial cells by the peptide transporter PepT1 in cell and mouse experiments
Proposed / under investigation
- Reduces NF-κB and MAP-kinase inflammatory signaling in intestinal cells
- Acts at least partly independently of the MC1R melanocortin receptor that full α-MSH uses
Research Status & Evidence
Preclinical — no human data
Evidence comes from cell culture and mouse studies. FDA has stated it identified no human exposure data for KPV.
Types of evidence
- Available: Cell & lab studies
- Available: Animal studies
- Not available: Early human studies
- Not available: Clinical trials
- Not available: Approved medical use
Evidence comes from cell culture and mouse studies, mainly published around 2008 and later drug-delivery work. FDA has stated it identified no human exposure data for KPV by any route.
Areas of research
- Intestinal inflammationmouse colitis models
- Peptide transportPepT1-mediated uptake in gut cells
- Inflammatory signalingNF-κB pathway studies
Limitations
- Not approved by the FDA or any other regulator
- No human studies identified; FDA reports no human exposure data
- Findings in mouse colitis models have not been tested in people
Specifications
10 mg · Lyophilized powder · CAS 67727-97-3
- Product
- KPV
- Category
- Peptides
- Size
- 10 mg
- Form
- Lyophilized powder
- Synonyms
- Lys-Pro-Val; α-MSH (11–13); Lysine-proline-valine; KPV tripeptide
- CAS number
- 67727-97-3
- Molecular formula
- C16H30N4O4
- Molecular weight
- 342.43 g/mol
- Sequence
- Lys-Pro-Val (KPV)
- PubChem CID
- 125672
- SKU
- REN-KPV-10
Molecular data: Free peptide, per PubChem CID 125672; sequence per Dalmasso 2008. The salt form and net peptide content of each lot are stated on its Certificate of Analysis.
Testing & COA Batch report available
- Batch VB-2609-01-FJ · HPLC-DAD · Supplier COA (KMD Analytical) · 2026-10-0799.67% purity · Identity: confirmed · 10.74 mg measured (107.4% of label)View COA
Research References (3)
Linked sources · last reviewed October 2026
- Dalmasso G et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology 2008 · PubMed 18061177
- Kannengiesser K et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of IBD. Inflamm Bowel Dis 2008 · PubMed 18092346
- FDA. Certain bulk drug substances for use in compounding that may present significant safety risks (updated April 2026) · fda.gov
Summaries are written by Renuvia Labs from the sources above for educational context only. Last reviewed October 18, 2026.
Frequently Asked Questions
Is KPV third-party tested?
Every KPV lot is assigned a lot number and listed in the COA library, where its Certificate of Analysis (identity and purity report) is published when the lab issues it. Until the report is posted, the lot shows as pending; we do not quote a purity figure without the report.
Is there a KPV coupon or promo code?
No. Renuvia Labs has no KPV coupon code, and codes listed on coupon sites are not valid here. The discount that exists is a first-order offer earned by joining the Renuvia email list (applied at checkout when active), plus per-vial pricing that drops automatically at 2, 3 and 5 vials.
What size is the KPV vial?
KPV is supplied as a single 10 mg lyophilized vial (10 mg total peptide content stated on the label). Larger quantities are available through the wholesale program.
What is KPV?
KPV is a three-amino-acid peptide (lysine-proline-valine) taken from the end of α-MSH, a hormone with anti-inflammatory activity. It has been studied in intestinal cells and mouse models of colitis for its effects on inflammatory signaling. There are no human studies, and it is not approved.
Is there a KPV coupon or discount code?
There is no public coupon code. New customers get a first-order discount for joining the Renuvia email list, volume pricing starts at 2 vials of KPV, and U.S. shipping is free over $150. Codes on third-party coupon sites are not valid here.
What are other names for KPV?
KPV is also referred to as Lys-Pro-Val, α-MSH (11–13), Lysine-proline-valine, KPV tripeptide.
What are the CAS number and molecular weight of KPV?
KPV: CAS number 67727-97-3; molecular formula C16H30N4O4; molecular weight 342.43 g/mol; PubChem CID 125672. Sequence: Lys-Pro-Val (KPV). (Free peptide, per PubChem CID 125672; sequence per Dalmasso 2008. The salt form and net peptide content of each lot are stated on its Certificate of Analysis.)
What sizes is Renuvia Labs KPV available in?
KPV is listed in 10 mg, supplied as lyophilized powder in a sealed glass vial. It is sold for laboratory research use only.
Where is the Certificate of Analysis for KPV?
Certificates of Analysis are published per lot in the Renuvia Labs COA library, searchable by product, SKU or lot number. KPV shows "pending" there until the current lot's report exists; it is then linked on this page too.
Is this in stock?
Yes, unless the page says sold out. You reserve it with no payment today, and we email payment instructions in approximately 1–2 business days. Your order ships once payment arrives.
What form is this product supplied in?
Peptides and research compounds ship as lyophilized (freeze-dried) powder in a sealed glass vial. The fill amount printed on the product page and label is the total content of the vial.
Is this product for human use?
No. All Renuvia Labs products are sold strictly for laboratory research use. They are not for human or animal consumption and are not intended to diagnose, treat, cure or prevent any disease.
Do you offer volume pricing?
Yes. Per-vial pricing drops automatically at 2, 3 and 5 vials of the same product; the current tiers are shown next to the price. For larger quantities, see our wholesale program.
How much is shipping?
Free U.S. shipping on orders of $150 or more; $8.95 flat rate below that.
Do you ship outside the U.S.?
No. Renuvia Labs ships to U.S. addresses only. Research institutions outside the U.S. can enquire through the wholesale program.
