PT-141
In stock10 mg · Lyophilized powder
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Synthetic cyclic melanocortin-receptor peptide (bremelanotide).
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For laboratory research use only by qualified researchers. Not for human or veterinary use. Not a drug, dietary supplement, cosmetic or food. Not evaluated by the FDA for any use.
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Quick Summary
FDA-approved ingredient (Vyleesi, 2019) — one indicationPT-141 (bremelanotide) is a synthetic peptide that activates melanocortin receptors, a signaling system involved in pigmentation, appetite and sexual motivation. Bremelanotide is FDA-approved as Vyleesi for one condition: acquired, generalized hypoactive sexual desire disorder in premenopausal women. This research-grade material is not that approved drug product.
Areas of research
- Melanocortin receptor pharmacology
- Hypoactive sexual desire disorder
- Central nervous system signaling
- Pigmentation
- Amount
- 10 mg
- Form
- Lyophilized powder
- References
- 2 cited
- COA
- Published
- Free U.S. shipping on orders of $150 or more
- Lyophilized powder in a sealed vial
- Batch COA available
Research Use Notice. This product is intended for laboratory and research purposes. It is not intended for human consumption or personal medical use. Product information is provided for scientific and educational context only. See our Research Use Policy.
Why Researchers Study It
- Melanocortin receptor pharmacology, especially the MC4R receptor in the brain
- Brain pathways of sexual motivation, the basis of its approval
- Skin darkening through the MC1R receptor, reported in trials
- Its close structural relationship to melanotan II
What It Is
PT-141 is the development name of bremelanotide, a synthetic cyclic peptide of seven amino acids that activates melanocortin receptors.
PT-141 is the development name of bremelanotide, a synthetic cyclic peptide of seven amino acids that activates melanocortin receptors. It is structurally very close to melanotan II, differing mainly at the end of the peptide chain.
Bremelanotide is the active ingredient of Vyleesi, an FDA-approved prescription medicine. This research-grade material is not that approved drug product.
Most melanocortin research focuses on pigmentation, appetite and inflammation. Bremelanotide is of interest because it acts on melanocortin receptors in the brain that are involved in sexual motivation.
Its clinical program led to FDA approval in 2019 for a narrowly defined condition in premenopausal women. The label notes that how it works for that condition is not known.
How It Works
2 established · 1 proposed or under investigation
Established
- Non-selective agonist at melanocortin receptors, most potent at MC1R and MC4R (per the FDA label)
- Activation of MC1R on pigment cells explains the focal skin darkening reported in trials
Proposed / under investigation
- Effects on sexual desire are thought to involve MC4R signaling in the brain; the FDA label states the mechanism for its approved use is unknown
Research Status & Evidence
FDA-approved ingredient (Vyleesi, 2019) — one indication
Approved only for one condition in one population. This product is research-grade material, not the approved drug.
Types of evidence
- Not available: Cell & lab studies
- Available: Animal studies
- Not available: Early human studies
- Available: Clinical trials
- Available: Approved medical use
Bremelanotide went through randomized controlled trials and has an FDA-approved use, which makes its evidence base stronger than most research peptides. That approval is limited to one indication in one population; evidence outside it is limited.
Areas of research
- Melanocortin receptor pharmacologyMC1R and MC4R agonism
- Hypoactive sexual desire disorderthe basis of its FDA approval
- Central nervous system signalingbrain pathways of sexual motivation
- Pigmentationskin darkening as an MC1R-mediated effect
Limitations
- Approved (as Vyleesi) only for acquired, generalized hypoactive sexual desire disorder in premenopausal women; the label states it is not indicated for postmenopausal women or men, or to enhance sexual performance
- In trials about 40% of participants reported nausea; transient blood-pressure increases and focal skin darkening (sometimes permanent) were also reported
- Research-grade material is not the FDA-approved drug product and is not made under drug manufacturing standards
Specifications
10 mg · Lyophilized powder · CAS 189691-06-3
- Product
- PT-141
- Category
- Peptides
- Size
- 10 mg
- Form
- Lyophilized powder
- Synonyms
- Bremelanotide; PT-141
- CAS number
- 189691-06-3
- Molecular formula
- C50H68N14O10
- Molecular weight
- 1025.2 g/mol
- PubChem CID
- 9941379
- SKU
- REN-PT141-10
Molecular data: Free peptide (FDA Global Substance Registration System).
Testing & COA Batch report available
- Batch VB-2609-01-DM · HPLC-DAD · Supplier COA (KMD Analytical) · 2026-10-0799.68% purity · Identity: confirmed · 10.55 mg measured (105.5% of label)View COA
Research References (2)
Linked sources · last reviewed September 2026
- FDA. VYLEESI (bremelanotide injection) prescribing information, 2019 · accessdata.fda.gov
- FDA Global Substance Registration System: Bremelanotide (UNII 6Y24O4F92S) · gsrs.ncats.nih.gov
Summaries are written by Renuvia Labs from the sources above for educational context only. Last reviewed September 28, 2026.
Frequently Asked Questions
Is PT-141 the same as bremelanotide?
Yes. PT-141 is the development code for bremelanotide. Renuvia Labs lists it as PT-141, 10 mg, as research material only.
What is PT-141?
PT-141 (bremelanotide) is a synthetic peptide that activates melanocortin receptors, a signaling system involved in pigmentation, appetite and sexual motivation. Bremelanotide is FDA-approved as Vyleesi for one condition: acquired, generalized hypoactive sexual desire disorder in premenopausal women. This research-grade material is not that approved drug product.
Is there a PT-141 coupon or discount code?
There is no public coupon code. New customers get a first-order discount for joining the Renuvia email list, volume pricing starts at 2 vials of PT-141, and U.S. shipping is free over $150. Codes on third-party coupon sites are not valid here.
What are other names for PT-141?
PT-141 is also referred to as Bremelanotide, PT-141.
What are the CAS number and molecular weight of PT-141?
PT-141: CAS number 189691-06-3; molecular formula C50H68N14O10; molecular weight 1025.2 g/mol; PubChem CID 9941379. (Free peptide (FDA Global Substance Registration System).)
What sizes is Renuvia Labs PT-141 available in?
PT-141 is listed in 10 mg, supplied as lyophilized powder in a sealed glass vial. It is sold for laboratory research use only.
Where is the Certificate of Analysis for PT-141?
Certificates of Analysis are published per lot in the Renuvia Labs COA library, searchable by product, SKU or lot number. PT-141 shows "pending" there until the current lot's report exists; it is then linked on this page too.
Is this in stock?
Yes, unless the page says sold out. You reserve it with no payment today, and we email payment instructions in approximately 1–2 business days. Your order ships once payment arrives.
What form is this product supplied in?
Peptides and research compounds ship as lyophilized (freeze-dried) powder in a sealed glass vial. The fill amount printed on the product page and label is the total content of the vial.
Is this product for human use?
No. All Renuvia Labs products are sold strictly for laboratory research use. They are not for human or animal consumption and are not intended to diagnose, treat, cure or prevent any disease.
Do you offer volume pricing?
Yes. Per-vial pricing drops automatically at 2, 3 and 5 vials of the same product; the current tiers are shown next to the price. For larger quantities, see our wholesale program.
How much is shipping?
Free U.S. shipping on orders of $150 or more; $8.95 flat rate below that.
Do you ship outside the U.S.?
No. Renuvia Labs ships to U.S. addresses only. Research institutions outside the U.S. can enquire through the wholesale program.
