NAD+
In stock1000 mg · Lyophilized powder
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Nicotinamide adenine dinucleotide, 1000 mg.
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For laboratory research use only by qualified researchers. Not for human or veterinary use. Not a drug, dietary supplement, cosmetic or food. Not evaluated by the FDA for any use.
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Quick Summary
Established biology — not an approved drugNAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell, where it carries electrons in the reactions that produce energy. It is also used by enzymes involved in DNA repair and cell signaling. Aging research has focused on NAD+ decline, mostly using precursor molecules; NAD+ itself has been studied far less in people.
Areas of research
- Cellular energy metabolism
- Aging biology
- Sirtuin and PARP biology
- NAD+ pharmacokinetics
- Precursor comparison
- Amount
- 1000 mg
- Form
- Lyophilized powder
- References
- 4 cited
- COA
- Published
- Free U.S. shipping on orders of $150 or more
- Lyophilized powder in a sealed vial
- Batch COA available
Research Use Notice. This product is intended for laboratory and research purposes. It is not intended for human consumption or personal medical use. Product information is provided for scientific and educational context only. See our Research Use Policy.
Why Researchers Study It
- Its central role in cellular energy metabolism
- Enzymes that depend on it: sirtuins, PARPs and CD38, involved in DNA repair and signaling
- Age-related decline of NAD+ in many tissues
- How NAD+ itself compares with precursors such as NR and NMN
What It Is
NAD+ (nicotinamide adenine dinucleotide, also called nadide) is a coenzyme found in every living cell.
NAD+ (nicotinamide adenine dinucleotide, also called nadide) is a coenzyme found in every living cell. It carries electrons in the chemical reactions that turn food into usable energy.
This product is NAD+ itself, not one of its precursors. Nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), nicotinamide and nicotinic acid are different, smaller molecules that cells can convert into NAD+.
Beyond energy metabolism, NAD+ is consumed by enzyme families involved in DNA repair and cell signaling, including sirtuins, PARPs and CD38. Studies in animals and humans report that NAD+ levels fall in many tissues with age, and raising them improved several age-related problems in rodents.
Most human research has tested precursors taken by mouth rather than NAD+ itself. Direct NAD+ has been studied far less; one small pilot study measured how blood and urine levels changed during an intravenous infusion.
How It Works
3 established · 1 proposed or under investigation
Established
- Acts as a redox coenzyme, shuttling electrons in energy-producing reactions
- Serves as a required substrate for sirtuins, PARPs and CD38
- Cells build NAD+ from tryptophan or recycle it from precursors through salvage pathways
Proposed / under investigation
- How well supplied NAD+ reaches the inside of cells is uncertain; a major review states most mammalian cells, except neurons, cannot import it directly
Research Status & Evidence
Established biology — not an approved drug
NAD+'s role in cells is textbook science. Evidence on supplying NAD+ comes mainly from animal studies and small human pilot studies.
Types of evidence
- Available: Cell & lab studies
- Available: Animal studies
- Available: Early human studies
- Not available: Clinical trials
- Not available: Approved medical use
NAD+ biochemistry is textbook-level established science. Evidence that raising NAD+ changes health outcomes comes mainly from animal studies and small precursor trials in humans. For NAD+ itself, published human data are very limited: in one pilot study of eight adults, plasma NAD+ did not change for the first two hours of infusion, then rose.
Areas of research
- Cellular energy metabolismredox chemistry and mitochondria
- Aging biologyage-related NAD+ decline in tissues
- Sirtuin and PARP biologyNAD+-consuming signaling and DNA repair enzymes
- NAD+ pharmacokineticsplasma and urine changes during infusion
- Precursor comparisonNR and NMN versus direct NAD+
Limitations
- NAD+ is not an FDA-approved drug for any condition
- Most human studies test oral precursors (NR, NMN), so their results cannot be assumed to apply to NAD+ itself
- Human data on directly administered NAD+ come from very small, short, uncontrolled or pilot studies
- Whether boosting NAD+ benefits aging humans remains an open question in major reviews
Specifications
1000 mg · Lyophilized powder · CAS 53-84-9
- Product
- NAD+
- Category
- Research Compounds
- Size
- 1000 mg
- Form
- Lyophilized powder
- Synonyms
- Nicotinamide adenine dinucleotide; β-NAD; Nadide; beta-NAD+
- CAS number
- 53-84-9
- Molecular formula
- C21H27N7O14P2
- Molecular weight
- 663.4 g/mol
- PubChem CID
- 5892
- SKU
- REN-NAD-1000
Molecular data: Nadide, NAD+ as the neutral inner salt (PubChem).
Testing & COA Batch report available
- Batch RN-2610-NAD · HPLC-UV (purity), LC-MS (identity) · Freedom Diagnostics Testing · 2026-10-3199.31% purity · Identity: confirmed · 1,012.60 mg measured (101.3% of label). The lab report lists the sample as the "Black Cap" vialView COA
Research References (4)
Linked sources · last reviewed September 2026
- Rajman L, Chwalek K, Sinclair DA. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metab 2018 · PubMed 29514064
- Covarrubias AJ et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol 2021 · nature.com
- Grant R et al. A pilot study investigating changes in the human plasma and urine NAD+ metabolome during a 6-hour intravenous infusion of NAD+. Front Aging Neurosci 2019 · frontiersin.org
- PubChem. Nadide (NAD+), CID 5892 · pubchem.ncbi.nlm.nih.gov
Summaries are written by Renuvia Labs from the sources above for educational context only. Last reviewed September 28, 2026.
Frequently Asked Questions
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell, where it carries electrons in the reactions that produce energy. It is also used by enzymes involved in DNA repair and cell signaling. Aging research has focused on NAD+ decline, mostly using precursor molecules; NAD+ itself has been studied far less in people.
Is there a NAD+ coupon or discount code?
There is no public coupon code. New customers get a first-order discount for joining the Renuvia email list, volume pricing starts at 2 vials of NAD+, and U.S. shipping is free over $150. Codes on third-party coupon sites are not valid here.
What are other names for NAD+?
NAD+ is also referred to as Nicotinamide adenine dinucleotide, β-NAD, Nadide, beta-NAD+.
What are the CAS number and molecular weight of NAD+?
NAD+: CAS number 53-84-9; molecular formula C21H27N7O14P2; molecular weight 663.4 g/mol; PubChem CID 5892. (Nadide, NAD+ as the neutral inner salt (PubChem).)
What sizes is Renuvia Labs NAD+ available in?
NAD+ is listed in 1000 mg, supplied as lyophilized powder in a sealed glass vial. It is sold for laboratory research use only.
Where is the Certificate of Analysis for NAD+?
Certificates of Analysis are published per lot in the Renuvia Labs COA library, searchable by product, SKU or lot number. NAD+ shows "pending" there until the current lot's report exists; it is then linked on this page too.
Is this in stock?
Yes, unless the page says sold out. You reserve it with no payment today, and we email payment instructions in approximately 1–2 business days. Your order ships once payment arrives.
What form is this product supplied in?
Peptides and research compounds ship as lyophilized (freeze-dried) powder in a sealed glass vial. The fill amount printed on the product page and label is the total content of the vial.
Is this product for human use?
No. All Renuvia Labs products are sold strictly for laboratory research use. They are not for human or animal consumption and are not intended to diagnose, treat, cure or prevent any disease.
Do you offer volume pricing?
Yes. Per-vial pricing drops automatically at 2, 3 and 5 vials of the same product; the current tiers are shown next to the price. For larger quantities, see our wholesale program.
How much is shipping?
Free U.S. shipping on orders of $150 or more; $8.95 flat rate below that.
Do you ship outside the U.S.?
No. Renuvia Labs ships to U.S. addresses only. Research institutions outside the U.S. can enquire through the wholesale program.
