Tesamorelin
Pre-Order5 mg · Lyophilized powder
Available for pre-order
Synthetic 44-amino-acid GHRH analogue (TH9507).
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. For laboratory research use only. Not for human or animal consumption.
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Quick Summary
FDA-approved ingredient (Egrifta, 2010) — one indicationTesamorelin is a synthetic version of growth hormone-releasing hormone (GHRH), the brain signal that tells the pituitary gland to release growth hormone. It keeps all 44 amino acids of the natural hormone and adds a small chemical group that makes it more stable. Tesamorelin is the active ingredient of Egrifta, an FDA-approved medicine for one condition; this research-grade material is not that approved drug product.
Areas of research
- HIV-associated lipodystrophy
- Liver fat and NAFLD in people with HIV
- Growth hormone axis physiology
- Anti-doping science
- Amount
- 5 mg
- Form
- Lyophilized powder
- References
- 6 cited
- COA
- Batch report pending
- Free U.S. shipping over $150
- Lyophilized powder in a sealed vial
Research Use Notice. This product is intended for laboratory and research purposes. It is not intended for human consumption or personal medical use. Product information is provided for scientific and educational context only. See our Research Use Policy.
Why Researchers Study It
- Stimulating the body's own growth hormone release through the GHRH receptor
- Visceral (deep abdominal) fat in people with HIV, the basis of its approval
- Liver fat and fatty liver disease in people with HIV, studied in randomized trials
- How full-length, stabilized GHRH analogues compare with shorter fragments such as sermorelin
- Anti-doping detection, as a GHRH analogue on WADA's prohibited list
What It IsTesamorelin (development code TH9507) is a synthetic peptide made of all 44 amino acids of human growth hormone-releasing hormone (GHRH), with a tr…
Tesamorelin (development code TH9507) is a synthetic peptide made of all 44 amino acids of human growth hormone-releasing hormone (GHRH), with a trans-3-hexenoyl group attached to the first amino acid, tyrosine. The added group makes the peptide more resistant to breakdown than the natural hormone.
It was developed by Theratechnologies in Canada. The FDA approved it in 2010 as Egrifta, and later formulations (Egrifta SV and, in 2025, Egrifta WR) were approved for the same use. This research-grade material is not that approved drug product.
The approved use is narrow: reducing excess abdominal fat in adults with HIV who have lipodystrophy, a change in body-fat distribution linked to HIV and its treatment. The FDA label states that it is not indicated for weight loss and that its long-term cardiovascular safety has not been established.
Sermorelin, another GHRH-based peptide, contains only the first 29 amino acids of the natural hormone. Tesamorelin is the full-length hormone with a stabilizing modification.
How It Works2 established · 2 proposed or under investigation
Established
- Binds GHRH receptors on the pituitary gland and stimulates the production and pulse-like release of the body's own growth hormone (FDA label)
- Raises IGF-1, the hormone produced mainly by the liver in response to growth hormone (FDA label)
Proposed / under investigation
- The reduction in visceral fat is attributed to growth hormone's fat-breaking (lipolytic) effects; how much each downstream signal contributes is not fully defined
- Reductions in liver fat in people with HIV are being studied as a possible effect on fatty liver disease; this is not an approved use
Research Status & EvidenceFDA-approved ingredient (Egrifta, 2010) — one indication
Approved only to reduce excess abdominal fat in adults with HIV and lipodystrophy. This product is research-grade material, not the approved drug.
Types of evidence
- Not available: Cell & lab studies
- Not available: Animal studies
- Not available: Early human studies
- Available: Clinical trials
- Available: Approved medical use
Tesamorelin has a real regulatory approval backed by phase 3 randomized trials in adults with HIV, in which visceral fat fell over 26 weeks compared with placebo. Later randomized trials in people with HIV studied liver fat. Evidence outside the HIV population is limited, and the label notes long-term cardiovascular safety has not been established.
Areas of research
- HIV-associated lipodystrophyapproved indication (excess abdominal fat)
- Liver fat and NAFLD in people with HIVrandomized trials
- Growth hormone axis physiologyGHRH receptor signaling
- Anti-doping sciencelisted by WADA as a GHRH analogue
Limitations
- FDA-approved only to reduce excess abdominal fat in adults with HIV and lipodystrophy; the label states it is not indicated for weight loss
- Long-term cardiovascular safety has not been established (FDA label)
- Label warnings include raised IGF-1, fluid retention, glucose intolerance or diabetes, hypersensitivity reactions and injection-site reactions
- In the approved-use trials, the visceral fat reduction was not maintained after treatment stopped
- Prohibited at all times in sport under the WADA Prohibited List
Specifications5 mg · Lyophilized powder · CAS 218949-48-5
- Product
- Tesamorelin
- Category
- Peptides
- Size
- 5 mg
- Form
- Lyophilized powder
- Synonyms
- TH9507; Tesamorelin acetate
- CAS number
- 218949-48-5
- Molecular formula
- C221H366N72O67S
- Molecular weight
- 5135.9 g/mol
- PubChem CID
- 16137828
- SKU
- REN-TESA-5
Molecular data: Free peptide, not the acetate salt (PubChem; molecular weight also on the FDA label).
Testing & COA Batch report pending
Research References (6)Linked sources · last reviewed September 2026
- FDA / DailyMed. EGRIFTA SV (tesamorelin) prescribing information, Theratechnologies, revised December 2025 · dailymed.nlm.nih.gov
- Falutz J et al. Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med 2007 · PubMed 18057338
- Falutz J et al. Effects of tesamorelin in HIV-infected patients with abdominal fat accumulation: a randomized placebo-controlled trial with a safety extension. J Acquir Immune Defic Syndr 2010 · PubMed 20101189
- Stanley TL et al. Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial. JAMA 2014 · PubMed 25038357
- Stanley TL et al. Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial. Lancet HIV 2019 · PubMed 31611038
- WADA. The 2026 Prohibited List, section S2.2.4 (copy published by JADCO) · jadco.gov.jm
Summaries are written by Renuvia Labs from the sources above for educational context only. Last reviewed September 30, 2026.
Frequently Asked Questions
What form is this product supplied in?
Peptides and research compounds ship as lyophilized (freeze-dried) powder in a sealed glass vial. The fill amount printed on the product page and label is the total content of the vial.
Is this product for human use?
No. All Renuvia Labs products are sold strictly for laboratory research use. They are not for human or animal consumption and are not intended to diagnose, treat, cure or prevent any disease.
Where can I find the Certificate of Analysis?
When a batch has a Certificate of Analysis, it is linked in the Testing & COA section of the product page and listed in the COA library, searchable by product, SKU or batch number.
Do you offer volume pricing?
Yes. Per-vial pricing drops automatically at 2, 3 and 5 vials of the same product; the current tiers are shown next to the price. For larger quantities, see our wholesale program.
How much is shipping?
U.S. orders of $150 or more ship free. Orders below that ship at a flat rate, shown in the cart.
