Semax
Pre-Order11 mg · Lyophilized powder
Available for pre-order
Synthetic heptapeptide analog of ACTH(4–7) with a Pro-Gly-Pro extension.
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Quick Summary
Early clinical research (Russia) — not FDA-approvedSemax is a synthetic seven-amino-acid peptide built from a short fragment of adrenocorticotropic hormone (ACTH 4–7) with a stabilizing Pro-Gly-Pro tail. It has been studied, mainly in Russia, in rat models for effects on brain-derived neurotrophic factor (BDNF) and experimental stroke. It is not FDA-approved, and independent replication is limited.
Areas of research
- Neurotrophin signaling
- Cerebral ischemia
- Peptide biology
- Amount
- 11 mg
- Form
- Lyophilized powder
- References
- 3 cited
- COA
- Batch report pending
- Free U.S. shipping over $150
- Lyophilized powder in a sealed vial
Research Use Notice. This product is intended for laboratory and research purposes. It is not intended for human consumption or personal medical use. Product information is provided for scientific and educational context only. See our Research Use Policy.
Why Researchers Study It
- ACTH fragments that affect the nervous system without the hormone's adrenal effects
- BDNF and TrkB signaling, a pathway involved in nerve-cell survival, in rat brain
- Experimental stroke (cerebral ischemia) models in rats
- Stabilizing short peptides against breakdown
What It IsSemax is a synthetic peptide of seven amino acids (Met-Glu-His-Phe-Pro-Gly-Pro).
Semax is a synthetic peptide of seven amino acids (Met-Glu-His-Phe-Pro-Gly-Pro). It combines a short fragment of adrenocorticotropic hormone, ACTH(4–7), with a Pro-Gly-Pro tail that slows its breakdown.
It was developed in Russia, where most of its research has been done. It is not approved by the FDA.
Fragments of ACTH were found to affect the nervous system without the hormone's effects on the adrenal glands. Semax is of research interest as a stabilized version of such a fragment.
Rat studies have linked it to changes in brain-derived neurotrophic factor (BDNF), a protein involved in nerve-cell survival, and to gene-expression changes after experimental brain ischemia.
How It Works0 established · 2 proposed or under investigation
Established
No mechanism of action has been firmly established for Semax.
Proposed / under investigation
- Increases BDNF and activation of its receptor TrkB in rat hippocampus
- Alters expression of immune- and vascular-related genes after cerebral ischemia in rats
Research Status & EvidenceEarly clinical research (Russia) — not FDA-approved
Most published work is in rats; clinical reports appear mainly in Russian-language literature.
Types of evidence
- Not available: Cell & lab studies
- Available: Animal studies
- Available: Early human studies
- Not available: Clinical trials
- Not available: Approved medical use
Most published work is in rats and comes from a small group of Russian institutes. Clinical reports exist mainly in Russian-language literature, with limited independent or international replication.
Areas of research
- Neurotrophin signalingBDNF and TrkB in rodents
- Cerebral ischemiarat models of stroke
- Peptide biologystabilized ACTH fragments
Limitations
- Not approved by the FDA or the European Medicines Agency
- FDA has stated it lacks sufficient information to know whether Semax would cause harm in humans
- Evidence is concentrated in a few research groups, with little independent replication
Specifications11 mg · Lyophilized powder · CAS 80714-61-0
- Product
- Semax
- Category
- Peptides
- Size
- 11 mg
- Form
- Lyophilized powder
- Synonyms
- Met-Glu-His-Phe-Pro-Gly-Pro; ACTH(4–7) Pro-Gly-Pro
- CAS number
- 80714-61-0
- Molecular formula
- C37H51N9O10S
- Molecular weight
- 813.9 g/mol
- Sequence
- Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
- PubChem CID
- 9811102
- SKU
- REN-SEMX-11
Molecular data: Free peptide (FDA Global Substance Registration System).
Testing & COA Batch report pending
Research References (3)Linked sources · last reviewed September 2026
- Dolotov OV et al. Semax, an analog of ACTH(4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res 2006 · PubMed 16996037
- Filippenkov IB et al. Novel insights into the protective properties of ACTH(4-7)PGP (Semax) at the transcriptome level following cerebral ischaemia–reperfusion in rats. Genes 2020 · mdpi.com
- FDA. Certain bulk drug substances for use in compounding that may present significant safety risks (updated April 2026) · fda.gov
Summaries are written by Renuvia Labs from the sources above for educational context only. Last reviewed September 28, 2026.
Frequently Asked Questions
What form is this product supplied in?
Peptides and research compounds ship as lyophilized (freeze-dried) powder in a sealed glass vial. The fill amount printed on the product page and label is the total content of the vial.
Is this product for human use?
No. All Renuvia Labs products are sold strictly for laboratory research use. They are not for human or animal consumption and are not intended to diagnose, treat, cure or prevent any disease.
Where can I find the Certificate of Analysis?
When a batch has a Certificate of Analysis, it is linked in the Testing & COA section of the product page and listed in the COA library, searchable by product, SKU or batch number.
Do you offer volume pricing?
Yes. Per-vial pricing drops automatically at 2, 3 and 5 vials of the same product; the current tiers are shown next to the price. For larger quantities, see our wholesale program.
How much is shipping?
U.S. orders of $150 or more ship free. Orders below that ship at a flat rate, shown in the cart.
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